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Selentra HP

Selentra HP

Feel Like Your Best Self Again.

Selentra HP™, powered by FEM-936™, supports women’s mid-life health.* Selentra HP supports the biological foundation of the menopause transition, backed by research and formulated for what comes next.* Take 1 capsule twice daily.

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MSRP: $129.00

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2 capsules daily / 30-days per bottle
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The Effects

The new blueprint for women’s longevity.

The menopause transition is long, complex, and different for every woman. Symptoms come and go and change over time. Hot flashes for one woman, disrupted sleep, or a shift in inflammatory balance for another. What's consistent is the underlying process: estrogen decline impacts gut barrier function, bone and immune health and hormonal regulation – long before symptoms make them visible.

Most approaches address symptoms one at a time as they appear. Selentra HP supports the underlying system: the gut-hormone-bone axis through which estrogen decline makes its widest impact. It's formulated with two clinically studied, patented ingredients built specifically for this transition. Selentra HP is hormone-free and appropriate whether or not you're using menopausal hormone therapy, so you don't have to choose between the two.

This is a critical inflection point where many women's health trajectory changes. The science is clear, the support is not: menopause is understudied, under-treated, and under-discussed, and most care addresses symptoms rather than root cause. We can change that by treating the underlying biology.

The Effects

Selentra HP:

Supports a healthy inflammatory response during menopause*

Supports a healthy inflammatory response during menopause*

Promotes skin health and connective tissue integrity*

Promotes skin health and connective tissue integrity*

Supports a healthy gut*

Supports a healthy gut*

Helps maintain healthy bone density and structure*

Helps maintain healthy bone density and structure*

Selentra HP

Calroy launches science-forward, mechanism-first products that hold up under scrutiny — in the clinic, in the research, and in people’s lives. I trust them to get women's health right.

Dr. Nicole Beurkens, PhD, CNS

Calroy Advisor

The Science

Beyond Hormones. Beyond Symptoms.

Women are underserved during the menopausal transition. Too many formulas aim to manage symptoms one at a time, rather than addressing the systems underneath them. Selentra HP targets the biological system that governs hormonal regulation, inflammatory balance, and skeletal health simultaneously during this transition. It’s foundational support. 

As hormones change during menopause, a self-reinforcing cycle emerges: estrogen decline affects gut barrier permeability, immune balance shifts, and hormone and bone health are impacted. Three systems, one cascade, one originating event.

The impacts aren’t contained in the gut. The whole body feels this change, and foundational support can make a difference.

Want to go deeper? Explore the Science Library

The Science
The Science

The Research

Clinically Validated. Peer-Reviewed. Trusted by Experts.

Selentra HP is powered by two clinically studied, patented ingredients, each supported by published, peer-reviewed clinical studies conducted in peri- and postmenopausal women, the population this formula was designed for.

In a 12-week, randomized, placebo-controlled trial of women ages 40–55, VMK223 was associated with measurable reductions in key inflammatory markers, including CRP and IL-6, two standard measures of systemic inflammation. These findings are consistent with support for a healthy inflammatory response during menopause, alongside improvements in the secondary endocrine markers cortisol and DHEA.

A separate published trial in the same population found measurable improvements in skin hydration (+28%), elasticity (+27%), and wrinkle depth (−28%) over 12-weeks, outcomes researchers connect to the same gut-barrier and immune pathway.

In a one-year clinical study, postmenopausal women taking OsteoCaf at 600 mg daily, the same dose used in Selentra HP, maintained stable bone mineral density at the majority of measured sites.

Explore the Research

Key Studies Include:

  • Supplementation with Postbiotic from Bifidobacterium Breve BB091109 Improves Immune Markers and Endocrine Function in Healthy Females (Motei et al., 2023)

  • Oral Postbiotic (VMK223) Supplementation Is Associated with Improved Instrumental Skin Appearance Parameters in Healthy Women Aged 40–55 Years (Pipino et al., 2026)

  • A Clinical Study of a Standardized Extract of Leaves of Dalbergia sissoo in Postmenopausal Women (Meeta et al., 2019)

Ingredients

Thoughtfully sourced, quality controlled, vegan 

Selentra HP™ is powered by FEM-936™, a new proprietary blend of two clinically studied, patented ingredients formulated to support this connected system.*

VMK223™ is a postbiotic, a newer class of gut-health ingredient that works differently from probiotics or prebiotics. Rather than introducing live bacteria, VMK223 delivers the beneficial compounds bacteria produce directly. Postbiotics don't depend on the microbiome to work, they deliver the benefits directly. VMK223 engages two key immune receptors: one that calms gut-driven immune responses, and one that strengthens the gut barrier itself.* That makes it predictable by design. Unlike probiotics, whose effects vary with each woman's existing microbiome, VMK223 works at the receptor level, so it behaves consistently regardless of a woman's individual gut makeup.

OsteoCaf™ is a patented extract of Dalbergia sissoo (Indian rosewood). Bone is living tissue, constantly being broken down and rebuilt. OsteoCaf promotes bone-building activity during the menopausal transition. It does this without hormonal activity, making it appropriate for any woman regardless of her history with hormone therapy.

Every batch of Selentra HP is produced under Calroy's Total Quality System, with strict compliance to FDA-defined current Good Manufacturing Practices (cGMP). Batch and test records are maintained to ensure guaranteed purity, potency, and quality.

  • Thoughtfully Sourced

  • Vegan

  • Quality Controlled

Ingredients
Ingredients

How to use

Take 2 capsules daily. 1 in the morning, 1 in the evening. Splitting the dose supports consistent biological signaling throughout the day. Can be taken with or without food. Each bottle provides a 30-day supply. Backed by Calroy's 45-day, 100% money-back guarantee.

  • 2Caps

    Per Day

  • 30Days

    per bottle

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    money-back guarantee

Frequently Asked Questions

Who should consider Selentra HP?

The four groups Selentra HP most clearly benefits include:

  • Women in early perimenopause
  • Women navigating perimenopause or menopause with or without MHT 
  • Any woman for whom bone health is a primary focus
  • Post-menopausal women who either desire or require ongoing support after MHT 

More broadly, Selentra HP is appropriate for women preparing for, or actively navigating, perimenopause or menopause who want to support the foundational systems that shift during this transition: gut health, immune regulation, hormonal balance, and bone health.* Selentra HP is formulated for long-term, proactive use rather than short-term symptom relief.* It is safe to take alongside or without MHT.

Always consult your healthcare provider if you have medical conditions or take prescription medications.

Is Selentra HP right for me if I'm on hormone therapy, or if I'm not?

Talk with your healthcare provider about how it fits into your complete wellness plan.

Yes, Selentra HP is appropriate for use with or without hormone therapy. Selentra HP works through non-hormonal pathways, so it's appropriate regardless of your hormone therapy status, history, or plans. For women using hormone therapy, it supports the gut-immune-bone systems that hormone therapy doesn't directly address. For women who aren't, it works entirely on its own.

How soon will I notice results?

When taking Selentra HP, the first signs are internal: within the first few weeks, inflammatory balance shifts. Between weeks eight and twelve, gut-barrier markers continue to regulate, and the first visible change usually surfaces in the skin, as hydration and elasticity measurably improve.* Alongside these shifts, Selentra HP supports metabolic resilience, helping the body keep energy and metabolism steady as hormones change.* Bone support continues to build over time, with remodeling markers shifting over the following months and bone mineral density holding steady across a year of continued use.*

Are there any side effects or interactions?

In most cases it can be taken alongside other supplements or medications, but consult your healthcare provider if you have medical conditions or prescriptions.

Selentra HP is generally well tolerated. Because VMK223 is a postbiotic rather than a live-culture probiotic, it doesn't typically cause the adjustment period some gut supplements produce.

I already take a bone supplement (Calcium, vitamin D, etc.) or menopause supplement (black cohosh, etc.). What would Selentra do in addition?

Many women end up taking multiple products during perimenopause and menopause to address a range of symptoms, including supplements intended to support bones, hot flashes, mental balance, and more. Selentra HP takes a brand new foundational, systems-based approach where we believe the biggest impact is possible. By targeting the root change that’s happening in the gut alongside immune balance, a systemic shift towards balance and health occurs that symptom management alone cannot achieve. Selentra HP is an amazing opportunity to give women a very precise root-cause tool that can really change the global picture of what’s happening with health.*

Calroy Health Sciences

Your health is more than a set of symptoms. It’s your story.

At Calroy, we’re here to help you write it: stronger, longer, and with greater vitality.*